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GSK2879552
GSK2879552

基本信息 产品名称 GSK2879552
英文名称 4-((4-((((1R,2S)-2-phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoic acid  
别名 GSK-2879552  
CAS 1401966-69-5  
分子式 C₂₃H₂₈N₂O₂  
分子量 364.48  

物化性质 bp
nD20  
density  
fp  
外观 淡黄色固体  

运输信息
UNNumber  
Class  
PG  
危险性描述  
安全性描述  

用途信息
用途 GSK2879552是组蛋白去甲基化酶LSD1口服活性不可逆抑制剂,具抗癌活性,临床1期。  

其它信息 GSK2879552 is an orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.
IC50 value:
Target: LSD1 inhibitor
Upon administration, GSK2879552 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the dimethylated form of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. LSD1, overexpressed in certain tumor cells, plays a key role in tumor cell growth and survival.


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